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The coiled structure of a protein.
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Improving AlphaFold2 by Teaching It To Focus on “Energetic Frustration”

By encouraging AlphaFold2 to focus on "energetic frustration", researchers have found a new way to predict how proteins change shape.
Diabetes equipment on an orange background.
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Type 2 Diabetes Rates Surge 20% in a Decade

A University of Georgia study reveals a 20% increase in Type 2 diabetes between 2012 and 2022, with significant impacts on older adults, low-income individuals, and Black communities.
A freshly-collected batch of venomous cone snails.
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Deadly Snail Venom Could Hold the Key to New Diabetes Treatments

Researchers discovered a hormone-like toxin in cone snail venom that mimics human somatostatin, regulating blood sugar and hormone levels with greater stability and specificity.
A figure of a human extending from a DNA strand.
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Scientists Unveil Hidden DNA Code That Controls Gene Activity

Researchers discovered a “spatial grammar” in DNA that controls gene activity based on the positioning of transcription factors. The discovery could reshape our understanding of genetic expression and disease.
Influenza A under a microscope.
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Key Avian Influenza Enzyme Mutates Enabling Virus Replication in Mammals

Researchers deciphered the structure of the avian influenza virus’s polymerase when it interacts with a human protein essential for the virus to replicate within the cell. These results can help scientists monitor the adaptability of bird flu strains.
Two elderly men playing chess on a park bench.
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Retroelement Epigenetic Clocks Offer New Insights into Biological Aging

Scientists have identified retroelement DNA markers that act as accurate epigenetic clocks for biological aging. The Retro-Age clock offers the potential for tracking anti-aging therapies.
Covid-19 viruses coming from a nostril.
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New Study Links Long COVID to Brain Inflammation and Low Cortisol Levels

CU Boulder researchers discovered that COVID-19 proteins left in the brain reduce cortisol levels, inflame the nervous system, and prime immune cells to overreact to stressors. This might explain the neurological symptoms of long COVID.
Purple neurons against a red background.
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Single Gene Knock-Out Causes Mice To Display Hallmark Behaviors of Autism

Knocking out a gene linked to brain circuitry leads to several hallmark behaviors of autism, a new study has found.
Protein structure.
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AI Tool Predicts Protein Functions in Cells and Tissues

A new approach captures how proteins act not in isolation but in their cellular and tissue environments. The model illuminates how surrounding cells and tissues influence protein behaviors involved in sustaining health and fueling disease.
Cells dividing.
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Researchers Pinpoint Key Protein for Flavivirus Replication

During infection, flavivirus core proteins migrate to the nucleus of host cells to aid viral replication. Researchers have identified a transporter protein, called importin-7 (IPO7), as crucial for the nuclear transport of Flaviviridae core proteins.
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