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Improving AlphaFold2 by Teaching It To Focus on “Energetic Frustration”
By encouraging AlphaFold2 to focus on "energetic frustration", researchers have found a new way to predict how proteins change shape.

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Type 2 Diabetes Rates Surge 20% in a Decade
A University of Georgia study reveals a 20% increase in Type 2 diabetes between 2012 and 2022, with significant impacts on older adults, low-income individuals, and Black communities.

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Deadly Snail Venom Could Hold the Key to New Diabetes Treatments
Researchers discovered a hormone-like toxin in cone snail venom that mimics human somatostatin, regulating blood sugar and hormone levels with greater stability and specificity.

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Key Avian Influenza Enzyme Mutates Enabling Virus Replication in Mammals
Researchers deciphered the structure of the avian influenza virus’s polymerase when it interacts with a human protein essential for the virus to replicate within the cell. These results can help scientists monitor the adaptability of bird flu strains.

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Retroelement Epigenetic Clocks Offer New Insights into Biological Aging
Scientists have identified retroelement DNA markers that act as accurate epigenetic clocks for biological aging. The Retro-Age clock offers the potential for tracking anti-aging therapies.

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New Study Links Long COVID to Brain Inflammation and Low Cortisol Levels
CU Boulder researchers discovered that COVID-19 proteins left in the brain reduce cortisol levels, inflame the nervous system, and prime immune cells to overreact to stressors. This might explain the neurological symptoms of long COVID.

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Single Gene Knock-Out Causes Mice To Display Hallmark Behaviors of Autism
Knocking out a gene linked to brain circuitry leads to several hallmark behaviors of autism, a new study has found.

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AI Tool Predicts Protein Functions in Cells and Tissues
A new approach captures how proteins act not in isolation but in their cellular and tissue environments. The model illuminates how surrounding cells and tissues influence protein behaviors involved in sustaining health and fueling disease.

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Researchers Pinpoint Key Protein for Flavivirus Replication
During infection, flavivirus core proteins migrate to the nucleus of host cells to aid viral replication. Researchers have identified a transporter protein, called importin-7 (IPO7), as crucial for the nuclear transport of Flaviviridae core proteins.
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